Slipped-Strand Dna

Slipped-Strand Dna

 Slipped-strand DNA structures can form within direct repeat DNA sequences, such as (CTG)n•(CAG)n and (CGG)n•(CCG)n (where "n" denotes a variable number of repetitions). They form following denaturation, after the strands become unwound, and during renaturation, when the strands come back together. To form slipped-strand DNA, the opposite strands come together in an out-of-alignment fashion, during renaturation. Expansion of such triplet repeats are features of certain neurological diseases.